Dual-Targeted Proteins Tend to be More Evolutionarily Conserved
نویسندگان
چکیده
منابع مشابه
The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.
The zeste-white 10 (zw10) and rough deal (rod) genes of Drosophila both encode kinetochore components, and mutations in either gene greatly increase the missegregation of sister chromatids during mitosis. Here, we present genetic, cytological and biochemical evidence for a close, evolutionarily conserved relationship between the ROD and ZW10 proteins. We show that the phenotypes caused by disru...
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After decades of ignominy as ‘junk’, ‘parasite’ or ‘selfish’, noncoding deoxyribonucleic acid (DNA) present in introns and intergenic regions has recently been recognized as symbolizing a rich fossil record of DNA sequences subject to variation and conservation throughout evolution. In addition to clusters of evolutionarily conserved genes in close proximity to one another, human chromosomes al...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2014
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msu221